School chemistry class rooms

I'm working with a large school project seaking LEED certification. The schools has both chemistry classes and technical spaces for upper grades. These spaces are equipped with enhanced ventilation with no recirculation to deal with potential fumes from painting and chimical experiments. However, due the nature of the use and safety demands, mostly water based paints and mild chemical are used. Should the class rooms be subject to the demand for underpressuration? Or could pressuration be handled in-room with separate supply and exhaust zones. If so, this leads to trouble conserning reaching acoustical performance demands for corridor-classrooms walls and doors. Chemistry class will be equipped with at least one fume cupbourd.